Why is a frameshift missense mutation more likely to have a severe effect on phenotype than a nucleotide-pair substitution missense mutation in the same protein? why is a frameshift missense mutation more likely to have a severe effect on phenotype than a nucleotide-pair substitution missense mutation in the same protein? a frameshift missense will cause the codons to be out of order, but a substitution missense does not change the order of the codons. a substitution missense mutation causes the protein to be shorter and thus non-functional. a substitution missense affects only one codon, but a frameshift missense affects all codons downstream of the frameshift. a frameshift missense mutation will cause an early stop codon, but a substitution missense might be silent.
glucose being an important energy yielding molecule is considered to be important for the synthesis of atp during cellular respiration. the glucose has to move from blood into different types of tissues to fulfill the energy requirements of those cells.
however, glucose is not a very small molecule. so it cannot easily move through diffusion or even facilitated diffusion from blood cells into the other cells.
if we talk about osmosis, it is the process of mainly movement of water molecules from higher to lower concentration, and that is not a reasonable option.
if we talk about active transport, it is the process which use the energy input in the form of atp, for the movement of substances like glucose in a direction opposite to the concentration gradient.i.e.from lower to higher concentration.
the active transport can be of two types that glucose molecules use for transport.primary active transport secondary active transport
hope it !
showing a photograph would make this a hell of alot easier